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I currently run Nuendo on an old PC: 4GB ram, single core, Win7 32b. I never had any issues with any sound board (and I tried Nuendo on at least seven or eight different hardware configs) and while I've encountered my share of bugs and crashes, I've always found quick solutions all over the internet. Once you get the hang of the basic controls and hotkeys, which should not take long, you are ready to explore complex edition possibilities. Not because it's complicated, but because of the sheer amount of options the software offers to best suit your working style and workflow.
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While initial installation and setup are fairly simple, getting the most out of Nuendo requires a lot of time.
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Nuendo 4 was my first DAW, and even though I've tried other options (some of them excellent, such as Reaper) I've always returned to it.
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